| Description | TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis |
| In vitro | TLR4-IN-C34在内毒素血症和坏死性小肠结肠炎的小鼠模型中减少了全身性炎症。 |
| Animal experiments | Experimental NEC was induced in 7 8 day old mice .TLR4-IN-C34 was administered via the oral route at a concentration of 1 mg/kg on each morning of the four day model. |
| molecular weight | 389.4 |
| Molecular formula | C17H27NO9 |
| CAS | 40592-88-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9 mg/mL (23.11 mM) |
| References | 1. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779. 2. Adegoke E O , Adeniran S O , Zeng Y , et al. Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells[J]. Journal of Applied Toxicology, 2019. |
| Citations | 1. Yi Y, Gao K, Lin P, et al. Staphylococcus aureus-Induced Necroptosis Promotes Mitochondrial Damage in Goat Endometrial Epithelial Cells. Animals. 2022, 12(17): 2218. |