| Description | AXC-715 trihydrochloride (T785 trihydrochloride) is a TLR7/TLR8 dual agonist for the synthesis of antibody-adjuvanted immunocouplings. The couplings are mostly programmed death ligand 1 (PD-L1) attached to one or more antibody structures of the adjuvant. |
| Synonyms | T785 trihydrochloride |
| molecular weight | 420.81 |
| Molecular formula | C18H28Cl3N5 |
| CAS | 2479276-17-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 42.08 mg/mL (100 mM), Sonication is recommended. |
| References | 1. Sung-Ju Moon, et al. Compositions containing, methods and uses of antibody-tlr agonist conjugates. WO2020168017A1. 2. Shelley Erin ACKERMAN, et al. Immunoconjugates targeting pd-l1. WO2020190734A1. |