| Description | TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells. |
| Target activity | TLR3:3.44 μM (in RAW 264.7 cells) |
| Synonyms | CU CPT 4a |
| molecular weight | 377.82 |
| Molecular formula | C18H13ClFNO3S |
| CAS | 1279713-77-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (132.34 mM) |
| References | 1. Cheng K , Wang X , Yin H . Small-Molecule Inhibitors of the TLR3/dsRNA Complex[J]. Journal of the American Chemical Society, 2011, 133(11):p.3764-3767. |