| Description | TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human. TLQP 21 acetate is a VGF-derived peptide with endocrine and extraendocrine properties. |
| In vitro | TLQP 21 acetate 通过激活 C3aR1 导致细胞内 Ca2+ 的增加。TLQP 21 acetate (3 μM)诱导的收缩效果可达乙酰胆碱促进的相应收缩效果的约69%[1]。 |
| Target activity | C3aR1:10.3 μM(EC50,mouse), C3aR1:68.8 μM(EC50,human) |
| molecular weight | 2492.8 |
| Molecular formula | C109H174N40O28 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22(12):1744-1753. 2. Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21(1):130. |