| Description | Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction. |
| In vivo | Calcium channel-modulator-1 (20 mg/kg ; p.o.) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure.[1] |
| Target activity | Aortic contraction:0.8 μM , Aortic contraction:0.8 μM |
| molecular weight | 579.45 |
| Molecular formula | C26H24Cl2N2O7S |
| CAS | 136941-70-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.79 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Sunkel CE, et al. Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. J Med Chem. 1992 ; 35(13):2407-2414. |