| Description | Tiaramide hydrochloride (FK-1160) is an anti-inflammatory drug that inhibits the action of mediators released from mast cells and has direct smooth muscle relaxant properties. |
| In vitro | tiaramide通过非阻断Ca进入和细胞内Ca动员或钙调蛋白拮抗作用的其他机制，抑制血小板PLA2[1]。 |
| Synonyms | FK-1160, NTA-194, FK 1160, FK1160, tiaramide |
| molecular weight | 392.3 |
| Molecular formula | C15H19Cl2N3O3S |
| CAS | 35941-71-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 65 mg/ml (165.69 mM) |
| References | 1. Takano S. Inhibition of phospholipase A2 by tiaramide in rabbit platelets. Jpn J Pharmacol. 1985 Nov;39(3):307-16. PubMed PMID: 3005729. 2. Iwasaki K, Noguchi H, Kamataki T, Kato R. Metabolism of tiaramide in vitro. I. Oxidative metabolism of tiaramide by human and rat liver microsomes. Xenobiotica. 1982 Apr;12(4):221-6. PubMed PMID: 7113258. 3. Takano S, Sakurai K, Suzuki T. Inhibitory effect of tiaramide of aggregation in vivo and on electrophoresis of rabbit platelets. Jpn J Pharmacol. 1980 Dec;30(6):905-12. PubMed PMID: 6264190. 4. Harvey JE, Jones P, Tanser AR. A trial of tiaramide in asthma. Allergy. 1985 Apr;40(3):198-201. PubMed PMID: 3887976. |