| Description | Norchlorcyclizine (C-10) is a partially selective NPR-B inhibitor. It also is an inhibitor of human tyrosyl-DNA phosphodiesterase 1. |
| Synonyms | C10, C-10, C 10, 1-(4-氯二苯甲基)哌嗪 |
| molecular weight | 286.8 |
| Molecular formula | C17H19ClN2 |
| CAS | 303-26-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 65 mg/ml (226.64 mM) |
| References | 1. Foo WY, Tay HY, Chan EC, Lau AJ. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochem Pharmacol. 2015 Oct 1;97(3):320-30. doi: 10.1016/j.bcp.2015.07.036. Epub 2015 Jul 31. PubMed PMID: 26239802. 2. Parant F, Moulsma M, Gagnieu MC, Lardet G. Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (PETINIA). Ther Drug Monit. 2005 Aug;27(4):457-62. PubMed PMID: 16044102. 3. Thavundayil JX, Hambalek R, Kin NM, Krishnan B, Lal S. Prolonged penile erections induced by hydroxyzine: possible mechanism of action. Neuropsychobiology. 1994;30(1):4-6. PubMed PMID: 7969858. |