| Description | THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.THZ-P1-2 induces cell death and mitochondrial damage, and can be used in the study of leukemias. |
| In vitro | 在 THP1、SEMK2、OCI/AML-2、HL60、SKM1和 NOMO1 细胞中，THZ-P1-2（10-100000 nM；72 小时）在所有六个 AML/ALL 细胞系中显示出抗增殖活性，IC50 值范围为 0.87 至 3.95 μM[1]。 |
| molecular weight | 531.61 |
| Molecular formula | C31H29N7O2 |
| CAS | 2058075-45-7 |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (150.49 mM), Sonication is recommended. |
| References | 1. Sivakumaren SC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020;27(5):525‐537.e6. 2. Lima K, Pereira-Martins DA, de Miranda LBL, Coelho-Silva JL, Leandro GDS, Weinhäuser I, Cavaglieri RC, Leal AM, da Silva WF, Lange APAL, Velloso EDRP, Griessinger E, Hilberink JR, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Machado-Neto JA. The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy. Blood Cancer J. 2022 Nov 9;12(11):151. |