| Description | Apilimod 2HCl (STA 5326 2HCl) is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation, IL-1β secretion, and cellular pyroptosis, and is used in the study of amyotrophic lateral sclerosis. |
| Synonyms | STA 5326 2HCl, AIT-101 2HCl |
| molecular weight | 491.41 |
| Molecular formula | C23H28Cl2N6O2 |
| CAS | 870087-37-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Baranov MV, et al. The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19. Cells. 2020 Dec 27;10(1):30. 2. Diego Sbrissa, et, al.Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation.PLoS One. 2018; 13(9): e0204532. |