| Description | Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) (TRH-OH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels. |
| In vitro | TRH促进新合成的生长激素(GH)和催乳素(PRL)释放，但不促进甲状腺刺激激素的释放。此外，在10(-9)至10(-7) M浓度范围内，TRH剂量相关地增加了新合成GH和PRL的释放。环状(His-Pro)剂量依赖性地促进了新合成GH的释放。TRH、环状(His-Pro)和hGHRH促进GH合成，而在10(-7) M浓度下，SRIF则抑制了该过程。TRH和hGHRH还促进了新合成的PRL释放到培养基中，而SRIF则有抑制作用。PRL的合成未受TRH-OH和环状(His-Pro)影响。垂体内GH和PRL的细胞内含量没有显著变化。TRH在GH和PRL的合成及释放方面发挥了重要作用[1]。 |
| Synonyms | TRH-OH |
| molecular weight | 363.37 |
| Molecular formula | C16H21N5O5 |
| CAS | 24769-58-2 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 11 mg/mL (30.27 mM) |
| References | 1. Kagabu Y , Mishiba T , Okino T , et al. Effects of Thyrotropin-Releasing Hormone and Its Metabolites, Cyclo(His-Pro) and TRH-OH, on Growth Hormone and Prolactin Synthesis in Primary Cultured Pituitary Cells of the Common Carp,Cyprinus carpio[J]. General & Comparative Endocrinology, 1998, 111(3):395-403. 2. Lopez-Barneo J , Castellano A , Toledo-Aral J . Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons.[J]. Proceedings of the National Academy of Sciences, 1990, 87(20):8150-8154. 3. Eleonore F , Richard W . The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications[J]. Frontiers in Neuroendocrinology, 2018:S0091302218300384-. |
Thyrotropin-Releasing Hormone (TRH), Free Acid
CAS No.: 24769-58-2
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) (TRH-OH) causes a variety of thyroidal and non-thyroidal effects
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