| Description | (E)-2-Decenoic acid (trans-2-Decenoic acid) is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. |
| In vitro | Trans-2-decenoic acid 并不抑制AI-2特异性信号的传递，而是抑制了用于其检测的荧光酶反应。随后发现了 trans-2-decenoic acid 的潜在生物学角色。它能够在不影响生长的浓度下，抑制机会性人类病原体Candida albicans从酵母形态到菌丝形态的转变。trans-2-decenoic acid 能够消除C. albicans特有的菌丝标志基因HWP1的表达。trans-2-decenoic acid 在结构上类似于跨界信号分子家族DSF的成员，是该家族中首个来自革兰阳性细菌（Streptococcus DSF, SDSF）的成员。SDSF 活性也在 S. mitis、S. oralis 和 S. sanguinis 中被发现，但在其他口腔细菌中未发现。SDSF 可能在人体中塑造多种Candida细菌生物膜的过程中起到重要作用[1]。 |
| Synonyms | trans-2-Decenoic acid, 反式-2-癸烯酸 |
| molecular weight | 170.25 |
| Molecular formula | C10H18O2 |
| CAS | 334-49-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (587.37 mM) |
| References | 1. Ramiro Vílchez, André Lemme, Ballhausen B , et al. Streptococcus mutans Inhibits Candida albicans Hyphal Formation by the Fatty Acid Signaling Molecule trans-2-Decenoic Acid (SDSF)[J]. Chembiochem, 2010, 11(11):1552-1562. 2. Hattori N , Nomoto H , Fukumitsu H , et al. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro[J]. Biomedical Research, 2007, 28(5):261-266. |