| Description | THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment. |
| In vitro | 脑切片的放射自显影显示，THK5351 选择性地与神经原纤维缠结结合，并且与 THK5117 相比具有更高的信背景比[1]. |
| In vivo | THK5351 在小鼠中显示出良好的药代动力学特性，并且没有发生氟脱除[1]。 |
| molecular weight | 327.35 |
| Molecular formula | C18H18FN3O2 |
| CAS | 1707147-26-9 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 30 mg/mL (91.65 mM), Sonication is recommended. |
| References | 1. Harada R, et al. 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J Nucl Med. 2016 Feb;57(2):208-14. 2. Ishiki A, et al. Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy. Eur J Neurol. 2017 Jan;24(1):130-136. |