| Description | Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF. |
| In vitro | 8-Gingerol具有抗氧化活性，能够在体外抑制超氧自由基、单线态氧、过氧化氢以及羟基自由基的生成（IC50分别为26.7、0.83、0.39和25.07 μmol/L）[1]。 |
| In vivo | 体内，Theaflavin 3,3'-digallate降低了小鼠LPS诱导的急性肺损伤模型中的TNF-α、IL-1β和IL-6的血清水平，并减少了肺水肿、肺充血和肺泡壁增厚。它还在体外抑制了破骨细胞的形成、极化和破骨过程，并以剂量依赖方式减少了小鼠体内由钛粒子引起的骨侵蚀及成熟破骨细胞的数量[3]。 |
| Synonyms | 茶黄素-3,3'-双没食子酸, 8-Gingerol, TFDG |
| molecular weight | 868.7 |
| Molecular formula | C43H32O20 |
| CAS | 30462-35-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (11.51 mM) Ethanol: 10 mg/mL |
| References | 1. Wu YY, et al. Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses. J Zhejiang Univ Sci B. 2011 Sep;12(9):744-51. 2. Tanaka T, et al. Increase of theaflavin gallates and thearubigins by acceleration of catechin oxidation in a new fermented tea product obtained by the tea-rolling processing of loquat ( Eriobotrya japonica ) and green tea leaves. J Agric Food Chem. 2009 Jul 8;57(13):5816-22. 3. Hu X, et al. Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway. Acta Biomater. 2017 Jan 15;48:479-488. |
| Citations | 1. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891. |