| Description | L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage. |
| Target activity | HIV-1 integrase:100 nM (IC50) |
| Synonyms | (-)-Chicoric acid, trans-Caffeoyltartaric acid, Chicoric acid, L-菊苣酸, dicaffeoyltartaric acid, 菊苣酸 |
| molecular weight | 474.37 |
| Molecular formula | C22H18O12 |
| CAS | 70831-56-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (105.4 mM) |
| References | 1. Xiao H , Wang J , Yuan L , et al. Chicoric Acid Induces Apoptosis in 3T3-L1 Preadipocytes through ROS-Mediated PI3K/Akt and MAPK Signaling Pathways[J]. Journal of Agricultural and Food Chemistry, 2013, 61(7):1509-1520. |
| Citations | 1. Jung D H, Lee A, Hwang Y H, et al.Therapeutic effects of Pulsatilla koreana Nakai extract on ovalbumin-induced allergic rhinitis by inhibition of Th2 cell activation and differentiation via the IL-4/STAT6/GATA3 pathway.Biomedicine & Pharmacotherapy.2023, 162: 114730. |