| Description | TAT peptide (YGRKKRRQRRR), originating from the human immunodeficiency virus-1 (HIV-1) transactivator of transcription (TAT), enhances the solubility and production of heterologous proteins[1]. This cell-penetrating peptide demonstrates significant potential in biotechnological applications. |
| In vitro | TAT（YGRKKRRQRRR）代表人类免疫缺陷病毒I型（HIV-1）TAT蛋白的第47至57个氨基酸。HIV-1 TAT蛋白的带正电的蛋白质传导域（TAT-PTD；TAT的第47至57个残基）能迅速跨越活细胞的质膜。这一特性被用于向细胞内递送蛋白质、药物和基因。TAT（YGRKKRRQRRR；TAT-PTD）能够通过被动扩散简单地穿越细胞膜的疏水性脂质双层[1]。 |
| molecular weight | 1559.83 |
| Molecular formula | C64H118N32O14 |
| CAS | 191936-91-1 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: Soluble |
| References | 1. Ziegler A, et al. Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters. Biophys J. 2004 Jan;86(1 Pt 1):254-63. |