| Description | TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECsin vitroand reverses or impairs the development of arthritis or mechano-allodynia. |
| molecular weight | 539.48 |
| Molecular formula | C23H28Cl2N6O3S |
| CAS | 945725-50-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Fujii et al (2012) Amelioration of collagen-induced arthritis by a novel S1P 1 antagonist with immunomodulatory activities. J.Immunol. 188 PMID: 22131329 2. Fujii et al (2012) Blocking S1P interaction with S1P 1 receptor by a novel competitive S1P 1 -selective antagonist inhibits angiogenesis. Biochem.Biophys.Res.Commun. 419 754 PMID: 22387544 |