| Description | Tartrazine (Acid Yellow 23) is a food additive that belongs to a class of artificial dyes and contains an azo group; it has significant genotoxic effect , may be harmful to health and its prolonged use could trigger carcinogenesis. |
| In vitro | 我们通过3-(4,5-二甲基-2-噻唑基)-2,5-二苯基-2H-四唑溴化物(MTT)试验评估了Tartrazine的细胞毒性，并通过彗星实验(碱性版本)检测了DNA修复反应。我们使用了不同浓度的染料，范围为0.25-64.0 mM。研究结果显示，Tartrazine没有细胞毒性效应。然而，所有测试浓度下该染料均表现出显著的遗传毒性效应。尽管大部分损伤能够被修复，但在24小时修复后，部分损伤仍高于阳性对照[2]。 |
| Synonyms | 酒石黄, FD&C Yellow No. 5, Acid Yellow 23, 酸性黄 23 |
| molecular weight | 534.36 |
| Molecular formula | C16H9N4Na3O9S2 |
| CAS | 1934-21-0 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 40 mg/mL (74.86 mM), Sonication is recommended. H2O: 45 mg/mL (84.21 mM), Sonication is recommended. |
| References | 1. Rovina K, Siddiquee S, Shaarani SM. A Review of Extraction and Analytical Methods for the Determination of Tartrazine (E 102) in Foodstuffs. Crit Rev Anal Chem. 2017 Jul 4;47(4):309-324. doi: 10.1080/10408347.2017.1287558. Epub 2017 Jan 27. 2. Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow.Anticancer Res. 2015 Mar;35(3):1465-74. |