| Description | JAMM protein inhibitor 2 (Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-) is an inhibitor of JAMM protease and can be used for anticancer studies. The IC50s are 10 μM, 46 μM, and 89 μM for thrombin, Rpn11, and MMP2, respectively. |
| Target activity | MMP2:89 μM, RPN11:46 μM, Thrombin:10 μM |
| Synonyms | Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]- |
| molecular weight | 338.44 |
| Molecular formula | C21H26N2O2 |
| CAS | 848249-35-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 4 mg/mL (11.82 mM), Sonication is recommended. |
| References | 1. Han-Jie Zhou, et al. Methods and compositions for jamm protease inhibition. WO2013123071A1 (compound 180) |