| Description | Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively. |
| Target activity | TrkA:0.622 nM, TrkB:2.28 nM, ROS1:0.207 nM, TrkC:0.980 nM |
| Synonyms | DS-6051b, AB-106 |
| molecular weight | 551.61 |
| Molecular formula | C29H34FN5O5 |
| CAS | 1505515-69-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (81.58 mM) |