| Description | 1. Talatisamine (12 μM) and TEA (5mM) inhibits the enhanced I(K) caused by Aβ4 oligomers, attenuates cytotoxicity of Aβ oligomers by restoring cell viability and suppressing K(+) loss related apoptotic response. 2. Talatisamine can therefore be considered as a leading compound worthy of further investigations. |
| Target activity | IK channel:146 μM |
| Synonyms | 塔拉乌头胺, 塔拉萨敏 |
| molecular weight | 421.57 |
| Molecular formula | C24H39NO5 |
| CAS | 20501-56-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 32 mg/mL(75.9 mM) Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble |
| References | 1. Song M K , Liu H , Jiang H L , et al. Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons.[J]. Neuroscience, 2008, 155(2):469-475. |