| Description | TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity. |
| In vivo | TABERSONINE HYDROCHLORIDE是一种从长春花中主要分离得到的吲哚生物碱，是治疗癌症和阿尔茨海默病（AD）的潜在候选化合物，然而，其抗炎作用尚未揭示。TABERSONINE HYDROCHLORIDE在体内改善了脂多糖（LPS）诱导的急性肺损伤（ALI）并在体外抑制了LPS介导的巨噬细胞激活。通过使用小鼠ALI模型，我们发现TABERSONINE HYDROCHLORIDE显著减轻了LPS引起的肺部病理损伤。TABERSONINE HYDROCHLORIDE还抑制了LPS介导的中性粒细胞浸润、MPO活性升高及TNF-α、IL-6和IL-1β的产生。此外，TABERSONINE HYDROCHLORIDE抑制了LPS诱导的如iNOS、NO和细胞因子等促炎介质的产生，通过抑制NF-κB和p38 MAPK/MK2信号通路。TABERSONINE HYDROCHLORIDE减少了TRAF6的K63连结型聚泛素化。综上所述，TABERSONINE HYDROCHLORIDE在体内外具有抗炎活性，是治疗ALI/ARDS的潜在治疗候选物[1]。 |
| Synonyms | 水甘草碱盐酸盐, 它波宁盐酸盐 |
| molecular weight | 372.89 |
| Molecular formula | C21H25ClN2O2 |
| CAS | 29479-00-3 |
| Storage | keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 40 mg/mL (107.27 mM) |
| References | 1. Zhang D , Li X , Hu Y , et al. Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination[J]. Biochemical Pharmacology, 2018:S0006295218301898. 2. Tabersonine Inhibits Amyloid Fibril Formation and Cytotoxicity of Aβ(1–42)[J]. ACS Chemical Neuroscience:-. |