| Description | Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. |
| In vitro | Qingyangshengenin B（Ot B）能够适度延长秀丽隐杆线虫（C. elegans）的寿命，延缓身体运动能力随年龄衰减的速度，并提高其抗压力能力。进一步研究寿命延长效应的分子机制显示，Ot B能激活FOXO转录因子DAF-16。对于寿命已经通过胰岛素/IGF-1样受体（daf-2）突变体延长的线虫，Ot B无法进一步延长其寿命。此外，Ot B的寿命延长效应还依赖于SIR-2.1和参与泛醌合成的酶CLK-1。 |
| Synonyms | 青阳参甙元B, 青阳参苷元B, Otophylloside B |
| molecular weight | 923.13 |
| Molecular formula | C49H78O16 |
| CAS | 106758-54-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mg/mL (5.42 mM) |
| References | 1. Yang, Jie, Wan, et al. The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans[J]. Natural Products and Bioprospecting, 2015, 5(4):177-183. |