| Description | T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM). |
| In vitro | T-00127_HEV1表现出比其他候选化合物更强的抗脊髓灰质炎病毒活性（EC50：0.77 μM）。在10 μM浓度下，GW5074和T-00127_HEV1与AN-12-H5相比几乎完全抑制PI4KB激酶活性（分别保留3%和5%的残余活性）[1]。 |
| Target activity | PI4KIIIβ:60 nM, Anti-poliovirus (PV):0.77 μM(EC50) |
| molecular weight | 411.5 |
| Molecular formula | C22H29N5O3 |
| CAS | 900874-91-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 6 mg/ml (14.58 mM), Sonication is recommended. |
| References | 1. Arita M, et al. Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol. 2011 Mar;85(5):2364-72. |