| Description | Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides. |
| Synonyms | Symplostatin-1 |
| molecular weight | 799.12 |
| Molecular formula | C43H70N6O6S |
| CAS | 212007-18-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Paul VJ, Mooberry SL, Corbett TH, Valeriote FA. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. J Nat Prod. 1998 Sep;61(9):1075-7. PubMed PMID: 9748368. 2. Salvador-Reyes LA, Engene N, Paul VJ, Luesch H. Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation. J Nat Prod. 2015 Mar 27;78(3):486-92. doi: 10.1021/np500931q. Epub 2015 Jan 30. PubMed PMID: 25635943; PubMed Central PMCID: PMC4724867. 3. Salvador LA, Paul VJ, Luesch H. Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. J Nat Prod. 2010 Sep 24;73(9):1606-9. doi: 10.1021/np100467d. Erratum in: J Nat Prod. 2016 Feb 26;79(2):452. PubMed PMID: 20806908; PubMed Central PMCID: PMC2965599. 4. Mooberry SL, Leal RM, Tinley TL, Luesch H, Moore RE, Corbett TH. The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog. Int J Cancer. 2003 Apr 20;104(4):512-21. PubMed PMID: 12584751. |