| Description | NS004 is a large-conductance K+ channel opener, it inhibits mitochondrial function in glioma cells. |
| Synonyms | NS 004, NS-004 |
| molecular weight | 328.67 |
| Molecular formula | C14H8ClF3N2O2 |
| CAS | 141797-92-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Nardi A, Calderone V, Chericoni S, Morelli I. Natural modulators of large-conductance calcium-activated potassium channels. Planta Med. 2003 Oct;69(10):885-92. Review. PubMed PMID: 14648389. 2. Dérand R, Bulteau-Pignoux L, Becq F. Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004. J Membr Biol. 2003 Jul 15;194(2):109-17. PubMed PMID: 14502435. 3. Debska G, Kicinska A, Dobrucki J, Dworakowska B, Nurowska E, Skalska J, Dolowy K, Szewczyk A. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem Pharmacol. 2003 Jun 1;65(11):1827-34. PubMed PMID: 12781334. 4. Al-Nakkash L, Hu S, Li M, Hwang TC. A common mechanism for cystic fibrosis transmembrane conductance regulator protein activation by genistein and benzimidazolone analogs. J Pharmacol Exp Ther. 2001 Feb;296(2):464-72. PubMed PMID: 11160632. |