| Description | SST-02 is a potent cationic lipid for siRNA-Lipid Nanoparticles. SST-02 possesses a simple chemical structure and is synthesized just in one step. SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02 LNP did not show changes in body weight, blood chemistry, or hematological parameters, while the AST level decreased at a dose of 5 mg/kg. The use of SST-02 avoids a lengthy synthetic route and may thus decrease the future cost of nucleic acid therapeutics. |
| Synonyms | SST 02, SST02 |
| molecular weight | 572.02 |
| Molecular formula | C39H73NO |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles Takeshi Kuboyama, Kaori Yagi, Tomoyuki Naoi, Tomohiro Era, Nobuhiro Yagi, Yoshisuke Nakasato, Hayato Yabuuchi, Saori Takahashi, Fumikazu Shinohara, Hiroto Iwai, Ayumi Koubara-Yamada, Kazumasa Hasegawa, and Atsushi Miwa Publication Date (Web): April 12, 2019 (Letter) doi: 10.1021/acsmedchemlett.8b00652 |