| Description | 4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1]. |
| Target activity | PqsR (P. aeruginosa):23.6 μM, Virulence factor pyocyanin:87.2 μM, PqsR (E. coli):12.5 μM |
| molecular weight | 193.24 |
| Molecular formula | C11H15NO2 |
| CAS | 62034-73-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Klein T, et al. Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptionalregulator PqsR: biophysically guided hit discovery and optimization. ACS Chem Biol. 2012 Sep 21;7(9):1496-501. |
4-(tert-Butyl)-benzhydroxamic Acid
CAS No.: 62034-73-5
4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginos
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