| Description | SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect. |
| In vivo | In CK-p25 mice, SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 . SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments. SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR). |
| molecular weight | 774.97 |
| Molecular formula | C40H54N8O6S |
| CAS | 1383551-17-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Gräff J, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci. 2013 May 22;33(21):8951-60. |