| Description | SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM). |
| Target activity | RORα:220 nM(ki) |
| Synonyms | ML 176 |
| molecular weight | 405.34 |
| Molecular formula | C13H9F6NO3S2 |
| CAS | 293753-05-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 30 mg/mL DMSO: 50 mg/mL (123.35 mM) |
| References | 1. Kumar N, et al. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6(3):218-22. 2. Sadeghi H, et al. The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita. J Pathol. 2015 Sep;237(1):111-22. |