| Description | SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM). |
| molecular weight | 477.4 |
| Molecular formula | C15H13F6N3O4S2 |
| CAS | 1335106-03-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (104.73 mM) H2O: Insoluble Ethanol: 45 mg/mL |
| References | 1. Solt LA, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011 Apr 28;472(7344):491-4. 2. Beurel E, et al. Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol Psychiatry. 2013 Apr 1;73(7):622-30. 3. Crumbley C, et al. Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS One. 2012;7(4):e33804. |