| Description | SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM). |
| In vitro | 在EL-4细胞中，SR2211抑制IL-23受体的表达和IL-17的细胞内染色[1]。 |
| Target activity | RORγ:320 nM, RORγ:105 nM(ki) |
| molecular weight | 527.48 |
| Molecular formula | C26H24F7N3O |
| CAS | 1359164-11-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (170.6 mM), Sonication is recommended. |
| References | 1. Kumar N, et al. Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol. 2012 Apr 20;7(4):672-7. 2. Song Y, et al. Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. Eur J Med Chem. 2016 Jun 30;116:13-26. |