| Description | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM). |
| In vitro | 处理3-Oxo-5β-cholanoic acid显著降低了RORγt报告基因的活性。3-Oxo-5β-cholanoic acid很可能通过与RORγt的物理相互作用来抑制TH17细胞的分化，并且抑制其转录活性。 |
| In vivo | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1]. |
| Synonyms | 3-氧代-5β-胆烷酸, Dehydrolithocholic acid |
| molecular weight | 374.56 |
| Molecular formula | C24H38O3 |
| CAS | 1553-56-6 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/ml (173.54 mM), Sonication is recommended. |
| References | 1. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148. |