| Description | Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity. |
| In vitro | Squalamine lactate has a more general effect on the cell signaling cascade, which is common to VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2]. |
| In vivo | When administered intravitreally and therefore requires intravenous dosing, Squalamine is ineffective . However, systemic dosing has yielded promising results in rats as well as humans[2]. |
| Synonyms | MSI-1256F |
| molecular weight | 718.04 |
| Molecular formula | C37H71N3O8S |
| CAS | 320725-47-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 36.66 mg/mL (51.06 mM) |
| References | 1. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246. 2. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88. |