| Description | Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ). |
| Target activity | Sspastn (human):99 nM |
| molecular weight | 382.51 |
| Molecular formula | C20H30N8 |
| CAS | 2351882-11-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 95 mg/mL (248.36 mM), Sonication is recommended. |
| References | 1. Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18. 2. Pisa R , Cupido T , Steinman J B , et al. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins[J]. Cell Chemical Biology, 2019, 26(9). |