| Description | Sodium zirconium cyclosilicate (UXSi-9) is a novel selective cation exchanger and a K+ binder that can be used to remove excess K+ from the body and can be used in the treatment of hyperkalemia. |
| In vitro | Sodium zirconium cyclosilicate (ZS-9) 是一种无机阳离子交换晶体化合物，具有高选择性截留单价阳离子的能力，特别是过量的 K+ 和铵离子[1]。 |
| In vivo | 在 Sprague-Dawley 大鼠中，Sodium zirconium cyclosilicate（2、4 和 6 g/kg；口服给药；每日一次，连续 5 天）能够在大鼠中达到 99% 的粪便回收率。并且以剂量依赖性方式吸收和去除钾离子[2]。 |
| Synonyms | UXSi-9 |
| molecular weight | 365.46 |
| Molecular formula | Na2O9Si3Zr |
| CAS | 17141-74-1 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Stavros F, et al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686. 2. Ash SR, et al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88(2):404-11. |