| Description | Sodium metatungstate (Sodium polyoxotungstate) is a potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase)(Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively). |
| Target activity | NTPDase2:28.8 μM (ki), NTPDase1:2.58 μM (ki), NTPDase3:3.26 μM (ki) |
| Synonyms | POM-1, 聚钨酸钠, Sodium polyoxotungstate |
| molecular weight | 2985.99 |
| Molecular formula | H2Na6O40W12 |
| CAS | 12141-67-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 48 mg/mL (16.07 mM), Sonication is recommended. H2O: 48 mg/mL (16.07 mM), Sonication is recommended. |
| References | 1. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7. 2. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8. |
| Citations | 1. Luo C, Liu X, Liu Y, et al.Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation.Inflammation.2023: 1-14. |