| Description | Sodium gualenate (Guaiazulenesulfonate sodium) (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound. It has anti-inflammatory and wound-healing effects. |
| In vivo | Sodium gualenate 经常用于治疗人类胃炎。其主要作用机制被定义为细胞保护，即保护胃黏膜[1]。 |
| Animal experiments | The anti-gastric ulcer activity of compounds was tested through an ethanol-induced gastric ulcer mouse model method.?Kunming mice, consisting of both males and females, each weighing about 25 g, were divided into groups of 8 at random.?The tested compounds, Omeprazole and guaiazulene derivatives which were made into suspensions using 5% CMC-Na were administered orally (0.4 mL/20 g) to the dose group, the drug reference group and the GAS-Na group respectively.?While the base control group was treated with only 5% CMC-Na.?Vehicle or test compounds were administered by the oral route once a day for five consecutive days.?After 0.5 h of the last dose, the mice were given orally 0.3 mL of anhydrous ethanol.?Half an hour after anhydrous ethanol administration, the animals were killed.?At last, the stomachs were removed and scored[1]. |
| Synonyms | Guaiazulenesulfonate sodium, 磺酸钠 |
| molecular weight | 300.35 |
| Molecular formula | C15H17NaO3S |
| CAS | 6223-35-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 30 mg/mL (99.88 mM) |
| References | 1. Cao T , Li Y , Yang Z , et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent[J]. Chemical Biology & Drug Design, 2016, 88(2):264-271. 2. Nakamichi K , Nakano T , Yasuura H , et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2003, 56(3):0-354. |