| Description | SOD1-Derlin-1 inhibitor-1 (SOD1-Derlin-1 Inhibitor 56-20) (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1 G93A -Derlin-1 complex with an IC 50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for amyotrophic lateral sclerosis research[1]. |
| In vitro | SOD1-Derlin-1 inhibitor-1（50 μM；16小时）抑制SOD1 G93A-Derlin-1复合体，IC 50 值为7.11 μM [1]。SOD1-Derlin-1 inhibitor-1（250 nM；6小时）优先与SOD1 G93A相互作用，Kd 值为81.1 μM [1]。 |
| Synonyms | SOD1-Derlin-1 Inhibitor 56-20 |
| molecular weight | 504.2 |
| Molecular formula | C19H12Br2N4OS |
| CAS | 840461-03-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1 mg/mL (1.98 mM), Sonication is recommended. |
| References | 1. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668. |