| Description | PFM39 is a selective MRE11 nucleic acid exonuclease inhibitor and Mirin analog that prolongs mitosis.PFM39 inhibits HR and alleviates repair defects caused by EXO1/BLM depletion. |
| In vitro | PFM39 （50 μM）作为 MRE11 核酸外切酶抑制剂， 能有效抑制同源重组 （HR） 而不会显着增加 NHEJ[1]. |
| molecular weight | 219.26 |
| Molecular formula | C10H9N3OS |
| CAS | 1310744-67-2 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (364.86 mM), Sonication is recommended. |
| References | 1. Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18. |