| Description | SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor). |
| In vitro | SNT207858 binds to MC-4 receptor with an affinity of 22 nM, and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5. |
| In vivo | In mice,the tumor induced weight loss significantly reduced by SNT207858 (30 mg/kg; oral administration; once daily; 15 days). |
| molecular weight | 616.62 |
| Molecular formula | C32H43Cl2N5O3 |
| CAS | 1104662-66-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 125 mg/mL (202.72 mM), Sonication is recommended. |
| References | 1. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. |