| Description | SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity. |
| Target activity | SMS2:100 nM (IC50), SMS1:56 μM (IC50) |
| Synonyms | SMS2 inhibitors |
| molecular weight | 369.78 |
| Molecular formula | C19H13ClFN3O2 |
| CAS | 2241838-28-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 250 mg/mL (676.08 mM) |
| References | 1. Mo M, Yang J, Jiang XC,et al.Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice[J].J Med Chem. 2018 Sep 27;61(18):8241-8254. |
| Citations | 1. Liang H, Ma X, Zhang Y, et al.The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells.Nature Cell Biology.2023: 1-12. |