| Description | 4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) has antidepressant-like, antidyslipidemic, and antihyperglycemic effects. It displays an insulinotropic activity. |
| In vitro | 4-Hydroxyisoleucine （4-OHIle），一种从胡芦巢（Trigonella foenum-graecum）种子中分离出的特殊非蛋白氨基酸，对与肥胖相关的胰岛素抵抗（IR）有着引人注目的效应。4-OHIle能增加葡萄糖诱导的胰岛素释放，且4-OHIle介导的胰岛素反应依赖于葡萄糖浓度。所观察到的有益效果涉及调节血糖、血浆甘油三酯、总胆固醇、游离脂肪酸水平以及改善肝功能。其作用机制与Akt磷酸化增加及Jun N末端激酶（JNK）1/2、细胞外信号调节激酶（ERK）1/2、p38有丝分裂原活化的蛋白激酶（MAPK）和核因子（NF）-κB的活化减少有关。4-Hydroxyisoleucine通过激活AMPK和抑制SOCS-3与IR-β亚单位以及IRS-1共免疫沉淀，减缓炎症介导的胰岛素抵抗。 |
| Synonyms | 4-羟基-L-异亮氨酸, 4-Hydroxy-L-isoleucine |
| molecular weight | 147.17 |
| Molecular formula | C6H13NO3 |
| CAS | 781658-23-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: Insoluble H2O: 10 mM |
| References | 1. Anaguiven A S , Ricardo C C , Jorge R , et al. 4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity[J]. Molecules, 2016, 21(11):1596-. 2. Gautam S , Ishrat N , Yadav P , et al. 4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1[J]. Molecular and Cellular Biochemistry, 2016, 414(1-2):95-104. |