| Description | SM-324405 is an agonist of TLR7. |
| In vivo | SM-324405 是一种TLR7激动剂，具有前药特性，是过敏性疾病免疫治疗的新型候选药物[1]。 |
| Synonyms | SM 324405 |
| molecular weight | 385.42 |
| Molecular formula | C19H23N5O4 |
| CAS | 677773-91-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9 mg/mL (23.35 mM) |
| References | 1. Kurimoto A, Hashimoto K, Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010 Apr 8 ;53(7):2964-72. 2. Biological characterization of a novel class of toll‐like receptor 7 agonists designed to have reduced systemic activity[J]. British Journal of Pharmacology, 2012, 166(2). |