| Description | SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively). |
| In vitro | SIRT-IN-1是一种SIRT1/2/3的强效抑制剂，其IC50值分别为0.015、0.010、0.033 μM。SIRT-IN-1在催化活性位点具有一致的结合模式（RMS=0.29 Å），通过占据了烟酰胺C-口袋和乙酰化赖氨酸底物通道。 |
| Target activity | SIRT1:15 nM, SIRT3:33 nM, SIRT2:10 nM |
| molecular weight | 389.52 |
| Molecular formula | C19H27N5O2S |
| CAS | 1431411-60-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.89 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79. |