| Description | N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM). |
| In vitro | 在细胞层面上，N-Caffeoyltryptophan能够增加神经元NG108-15细胞中总赖氨酸、cortactin和组蛋白H3的乙酰化水平。在同样的细胞中，这种酰胺还能增加p53中赖氨酸（K382）的乙酰化，但不影响（K305）[1]。 |
| Target activity | SIRT1:34μM, SIRT2:8.7 μM |
| Synonyms | trans-Caffeoyl-L-tryptophan, 反式咖啡酰-L-色氨酸 |
| molecular weight | 366.37 |
| Molecular formula | C20H18N2O5 |
| CAS | 109163-69-1 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (122.83 mM) |
| References | 1. Park JB. Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 Inhibitor. PLoS One. 2016 Mar 17;11(3):e0150392. |