| Description | SiR-COOH enables tracking of the model therapeutic drug's intracellular location in GFP cells, characterized by absorption (Abs) at 645 nm and emission (Em) at 676 nm. |
| In vitro | SiR-COOH可用于连接抑制剂，如UNC2025（Mer抑制剂）。SiR-COOH对于小分子探针尤其有利：它在近红外波长显示出明亮、光稳定的荧光，非常适合深组织成像；在生理环境中展示出强鲁棒的荧光，且毒性最小；适用于超高分辨率显微镜成像；并且具有适合活细胞成像的最佳亲水性水平。[2] |
| molecular weight | 472.61 |
| Molecular formula | C27H28N2O4Si |
| CAS | 1418275-26-9 |
| Storage | keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (105.8 mM) |
| References | 1. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7. 2. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45. |