| Description | MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.MHI-148 is taken up and accumulates in the lysosomes and mitochondria of tumor cells but is not taken up in the lysosomes and mitochondria of normal cells.MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection and diagnosis of cancer. |
| In vitro | 化合物MHI-148（10 µM；1小时）在HT-29结肠癌细胞中的吸收明显高于正常的NIH3T3成纤维细胞。[1] 同时，它在肿瘤成像和靶向性能方面也显示出其能力。[1] 在0至1.5 µM浓度范围内，MHI-148对HT-29和NIH3T3细胞（处理时间3天）几乎不表现出毒性。[1] |
| Synonyms | IR-808 |
| molecular weight | 764.23 |
| Molecular formula | C42H52BrClN2O4 |
| CAS | 172971-76-5 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 18.7 mg/mL (24.5 mM), Sonication is recommended. |
| References | 1. Raveendran A, et al. Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. Int J Nanomedicine. 2021;16:7169-7180. 2. Xia X, et al. Florescence Imaging Lung Cancer with a Small Molecule MHI-148. J Fluoresc. 2020;30(6):1523-1530. 3. Thomas RG,et al. MHI-148 Cyanine Dye Conjugated Chitosan Nanomicelle with NIR Light-Trigger Release Property as Cancer Targeting Theranostic Agent. Mol Imaging Biol. 2018;20(4):533-543. 4. Raveendran A, et al. Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. Int J Nanomedicine. 2021;16:7169-7180. |