| Description | SIC5-6 is a potent inhibitor of Separase, a substantial cysteine protease implicated in critical cellular processes such as chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, as well as spindle stabilization and elongation. Given its overexpression in many solid cancers, Separase presents an attractive target for chemotherapy [1]. |
| In vitro | SIC5-6（30 μM、100 μM）提升了HeLa细胞内Caspase-1的活性并促进Rad21的裂解。（Rad21是一种Separase裂解位点，其中结合了荧光染料Rh110（HY-D0817））[1] |
| molecular weight | 581.47 |
| Molecular formula | C27H24IN3O2S |
| CAS | 2410846-16-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |