| Description | Sesamin is a selective delta 5 desaturase inhibitor in the biosynthesis of polyunsaturated fatty acids and is a lignan abundantly present in sesame oil. It has potent neuroprotective effects against cerebral ischemia. |
| In vitro | 在小鼠中,灌胃Sesamin的LD50为3800 mg/kg;在大鼠中,灌胃Sesamin的LD50为6150 mg/kg. |
| In vivo | Sesamin能够显著增加脂肪酸氧化酶的肝脏活性（如酰基辅酶A脱氢酶,酰基辅酶A氧化酶,3-羟酰辅酶A脱氢酶,烯酰辅酶A水合酶和3-酮脂酰辅酶A硫解酶）,2,4-二烯酰-CoA还原酶和δ3,δ2-烯酰-CoA异构酶活性。 |
| Synonyms | Fagarol, Fsesamin, 芝麻素 |
| molecular weight | 354.35 |
| Molecular formula | C20H18O6 |
| CAS | 607-80-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 6.88 mg/mL (19.4 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Shimizu S, et al. Lipids, 1991, 26(7), 512-516. 2. Ashakumary L, et al. Metabolism, 1999, 48(10), 1303-1313. 3. Lim YP, et al. Evid Based Complement Alternat Med, 2012, 2012, 242810. 4. Dubey NK, et al. Plant Pathology in the 21st Century, 2009, 1, 181-198. |
| Citations | 1. Jang W Y, Kim M Y, Cho J Y.Antioxidant, Anti-Inflammatory, Anti-Menopausal, and Anti-Cancer Effects of Lignans and Their Metabolites.International Journal of Molecular Sciences.2022, 23(24): 15482. |