| Description | Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity |
| In vitro | Dipyrithione(PTS2)以剂量依赖的方式抑制了四种癌细胞系的增殖。与对照组细胞相比，处理后的细胞显示出收缩、不规则片段、凝结和分散的蓝色荧光粒子。PTS2诱导了细胞周期阻滞和细胞死亡。在PTS2处理的细胞中检测到caspase-9、caspase-3和PARP的裂解。与广泛使用的抗癌化合物及其前体相比，PTS2的抗肿瘤活性更为有效[1]。 |
| Cell experiments | Used MTT assays and trypan blue staining to test the viability of cancer cell lines. Hoechst 33258 and DAPI staining were used to observe cell apoptosis. Cell-cycle percentages were analyzed by flow cytometry. Apoptosis was assayed using caspase-3 and poly (ADP-ribose) polymerase (PARP) combined with Western blotting. Student's t-test was used for statistical analysis[1]. |
| molecular weight | 252.31 |
| Molecular formula | C10H8N2O2S2 |
| CAS | 3696-28-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 2.52 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Fan Y , Liu C , Huang Y , et al. Dipyrithione induces cell-cycle arrest and apoptosis in four cancer cell lines in vitro and inhibits tumor growth in a mouse model[J]. BMC Pharmacology and Toxicology, 2013, 14(1):1-8. 2. Xun, Song, Yuan-Xin, et al. In vivo antifungal activity of dipyrithione against Trichophyton rubrum on guinea pig dermatophytosis models.[J]. Biomedecine & Pharmacotherapie, 2018. |